Results and prospects of development of new polyphenolic drugs for cancer patients
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چکیده
The conference “Results and prospects of development of new polyphenolic drugs for cancer patients” took place at the N.N. Petrov National Medical Research Center of Oncology (PNMRCO) on May 31, 2017, and gathered researchers involved in development and evaluation of medicinal products based on the novel lignin-derived soluble polyphenolic polymer BP-Cx-1. BP-Cx-1 is the platform for a portfolio of innovative pharmacological products such as BP-C1, BP-C2 and BP-C3. Natural substances, as safe and pluripotent candidates for designing medicinal products, draw interest of various scientific communities. At the present time methods for extraction and characterization of individual polyphenolic compositions and a solid evidence-based scientific database on potential molecular targets of these compositions have been developed. Convincing nonclinical data, demonstrating, most of all, antioxidant properties of these compounds has been collected; some of these compositions (e.g., Genistein) are being evaluated in clinical trials. At the same time, the data on pharmacological potential of derivatives of lignin, plant polyphenolic polymer are very scarce. The conference “Results and prospects of development of new polyphenolic drugs for cancer patients” took place at the N.N. Petrov National Medical Research Center of Oncology (PNMRCO) on May 31, 2017, and gathered researchers involved in development and evaluation of medicinal products based on the novel lignin-derived soluble polyphenolic polymer BP-Cx-1. BP-Cx-1 is the platform for a portfolio of innovative pharmacological products such as BP-C1, BP-C2 and BPC3. BP-C1, a novel platinum-containing antineoplastic intramuscular drug developed for therapy of a number of cancer indications, is currently under evaluation in randomized clinical trials in patients with metastatic breast cancer. BP-C2, a novel radioprotector/radiomitigator, incorporating ammonium molybdate, is developed for supportive care of cancer patients treated with chemo/ radiotherapy. BP-C3, a novel pharmaceutical composition, comprising iron, selenium, A and C vitamins, is in animal studies as a geroprotector and a supportive care product for cancer patients. Over 150 international scientists from research Meeting Report
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